Fatty acid transporters in animal cells.

نویسندگان

  • T Y Hui
  • D A Bernlohr
چکیده

The mechanism by which fatty acids transverse the plasma membrane has been a controversial subject. Kinetic studies of fatty acid uptake suggested the presence of a protein carrier system in certain cells which exhibit rapid fatty acid influx and/or efflux such as hepatocytes, adipocytes and jejunal mucosal cells. Five plasma membrane proteins have been identified and proposed as candidates for fatty acid transporters thus far. These includes: Plasma Membrane Fatty Acid Binding Protein (FABPpm), Fatty Acid Translocase (FAT), caveolin, a 56-kDa renal fatty acid binding protein and Fatty Acid Transport Protein (FATP). The first four proteins were identified by classical biochemical techniques while FATP, the one most recently reported, was identified by expression cloning strategies. Each of these proteins has distinct primary amino acid sequence and tissue-specific pattern of expression. It remains to be determined whether the proteins identified to date function as individual polypeptides or as a single component of a larger complex. This review summarizes recent advances concerning the structure, function and regulation of these putative fatty acid transporters.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Role of fatty acid transporters in epidermis

Skin epidermis is an active site of lipid synthesis. The intercellular lipids of human stratum corneum (SC) are unique in composition and quite different from the lipids found in most biological membranes. The three major lipids in the SC are free fatty acids, cholesterol and ceramides. Fatty acids can be synthesized by keratinocytes de novo and, in addition, need to be taken up from the circul...

متن کامل

Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease.

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian homeostasis, particularly in the formation and dynamic properties of biological membranes and as fuels for energy production in tissues such as heart and skeletal muscle. On the other hand, long-chain fatty acid metabolites may exert toxic effects on cellular functions and cause cell injury. Therefore, fatty acid u...

متن کامل

Evaluation of Functional Properties and Fatty Acid Profiles of One-Hump and Crossbred (Dromedarius and Bactrianus) Camel Meat

In this study twenty-four male and female one-humped and crossbred (Camelus dromedarius and Camelus bactrianus) camel meat were evaluated during two fattening periods (6 and 9 months). The characteristics of camel meat and fatty acid profile in different parts of body (leg, shoulder, loin and neck) were measured. The results indicated that the pH ultimate of crossbred...

متن کامل

Effect of Slaughter Weight, Carcass Weight and Sex on the Carcass Fatty Acid Composition of Boutsiko Breed Lambs

The aim of the present study was to assess the effect of slaughter and carcass weight, age at slaughter and sex on the fatty acid profile of the Greek Boutsiko sheep breed. Twenty lambs (ten females and ten males) were examined. The lambs were slaughtered at the age of 48 days. Carcasses were chopped in nine specific cuts and a random sample of 100 g was taken from each cut, with a total of 180...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Frontiers in bioscience : a journal and virtual library

دوره 2  شماره 

صفحات  -

تاریخ انتشار 1997